[13] La Serena 0-1 CD Antofagasta [16] 2022-07-17 16:30
Stadium: La Portada Round: 18
Referee: Angelo Hermosilla Home Manager: Pablo Marini Away Manager: Javier Torrente
Head to Head
| Chile - Primera Division | 2022/02/19 23:30 | CD Antofagasta v La Serena | D | 2-2 |
| Chile - Primera Division | 2021/11/08 21:00 | CD Antofagasta v La Serena | D | 0-0 |
| Chile - Primera Division | 2021/08/02 18:30 | La Serena v CD Antofagasta | D | 1-1 |
| Chile - Primera Division | 2021/01/11 20:00 | CD Antofagasta v La Serena | D | 2-2 |
| Chile - Primera Division | 2020/02/03 22:30 | La Serena v CD Antofagasta | L | 0-1 |